C–H Bond Functionalization & Synthesis in the 21st Century: A Brief History and Prospectus

M. Christina White

doi:10.1055/s-0032-1317701

Synlett, Table of Contents

Synlett 2012; 23(19): 2746-2748
DOI: 10.1055/s-0032-1317701

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C–H Bond Functionalization & Synthesis in the 21^st Century: A Brief History and Prospectus

M. Christina White

Roger Adams Laboratory, Department of Chemistry, University of Illinois, Urbana, IL 61801, USA Fax: +1(217)2445943 Email: white@scs.uiuc.edu

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Abstract

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Abstract

Among the frontier challenges facing synthetic chemistry in the 21st century are the interconnected goals of increasing control of chemical reactivity and synthesizing complex molecules with higher levels of efficiency. Catalytic C–H bond functionalization reactions are increasingly being discovered that meet the criterion for useful reactivity (i.e. preparative, predictably selective, and general). Consequently, such reactions are enabling chemists to exploit strategies for complex molecule synthesis and derivatization previously accessible only in nature. This preface highlights some of the achievements and important challenges that remain in the area of C–H bond functionalization.�

Key words

C–H activation - site-selective oxidation - bio-inspired methods - synthetic efficiency - complex molecule synthesis

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References

References and Notes
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